Merck Sharpe & Dohme (MSD) – Major Upgrade to Pharmaceutical Reactor Bay & Hydrogenator Suite


MSD is the UK subsidiary of Merck & Co. Inc., a leading healthcare company that discovers, develops, manufactures and markets a wide range of innovative pharmaceutical products to improve human health.


MSD required HFL to carry out the design, procurement, installation, commissioning and re-validation of a major upgrade to a pharmaceutical reactor bay and Hydrogenator suite at their Hoddesdon site.


HFL was able to provide the required support which included:

  • Process – Specification of equipment and process modification work
  • Civil/Structural – Design of modified structures and fire walls
  • Mechanical/Piping – Procurement, expediting and inspection of all equipment, generation of
  • scope of work packages and production of ‘Issued for Construction’ drawing packages
  • Control – Modification of existing Delta V system
  • Electrical/Instrumentation – Specification of instruments, generation of scope work packages and production of ‘Issued for Construction’ drawing packages
  • Construction – All project preparation work, installation and commissioning supervised by an on site supervisor
  • Commissioning/Validation – Project fully commissioned, re-validated and handed over to the client


The major upgrade provided MSD with a fully operating Reactor Bay and Hydrogenator Suite which has allowed it to significantly increase production capacity and considerably reduce batch times.


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